Criteria to determine disability related to multiple sclerosis.

and Full-text Screening Criteria For each question, we developed fairly detailed instructions and decision rules for the screeners’ reference. There were very broad inclusion requirements for abstracts: MS study subjects and potential relevance to any of the five questions. For the full-text screening, screeners were asked to record their include/exclude decision, research question assignment, and, if appropriate, exclusion criteria that detailed insufficiencies in study design and clinical substance requirements. The titles and abstracts of the 1,487 articles were reviewed against the inclusion/exclusion criteria by at least two of five clinical investigators. The full text of each article passing the title-and-abstract screening was retrieved from the library for